Brain connectivity aberrations in anabolic-androgenic steroid users
نویسندگان
چکیده
Sustained anabolic-androgenic steroid (AAS) use has adverse behavioral consequences, including aggression, violence and impulsivity. Candidate mechanisms include disruptions of brain networks with high concentrations of androgen receptors and critically involved in emotional and cognitive regulation. Here, we tested the effects of AAS on resting-state functional brain connectivity in the largest sample of AAS-users to date. We collected resting-state functional magnetic resonance imaging (fMRI) data from 151 males engaged in heavy resistance strength training. 50 users tested positive for AAS based on the testosterone to epitestosterone (T/E) ratio and doping substances in urine. 16 previous users and 59 controls tested negative. We estimated brain network nodes and their time-series using ICA and dual regression and defined connectivity matrices as the between-node partial correlations. In line with the emotional and behavioral consequences of AAS, current users exhibited reduced functional connectivity between key nodes involved in emotional and cognitive regulation, in particular reduced connectivity between the amygdala and default-mode network (DMN) and between the dorsal attention network (DAN) and a frontal node encompassing the superior and inferior frontal gyri (SFG/IFG) and the anterior cingulate cortex (ACC), with further reductions as a function of dependency, lifetime exposure, and cycle state (on/off).
منابع مشابه
Serotonin-1A receptor activity and expression modulate adolescent anabolic/androgenic steroid-induced aggression in hamsters.
Repeated high dose (5.0 mg/kg) anabolic/androgenic steroid exposure during adolescence stimulates offensive aggression in male Syrian hamsters. These studies examined whether anabolic/androgenic steroid-induced aggression was regulated by the activity and expression of serotonin (5HT) type-1A receptors. In a first experiment, adolescent male hamsters were treated with a mixture of anabolic/andr...
متن کاملComparison of Personality Dark Trait and Behavioral Activation /Inhibition System in Bodybuilders with and without the Use of Anabolic-Androgenic Steroids
Over the past decade, the use of steroid medications has increased among athletes, especially bodybuilders who work professionally. Therefore, the present study was conducted to compare the dark trait personality and behavioral activation-inhibition system in bodybuilders with and without the use of anabolic-androgenic steroids. The present study was descriptive and casual-comparative. The stat...
متن کاملAnalysis of anabolic androgenic steroid use among male and female body builders of Torbat Heydariyeh in 2018
Background & Aim: The abuse of anabolic steroid is known as a major problem in many sport fields especially body building. On the other hands, anabolic steroids misuse might lead to serious and sometimes life-threatening health problems such as kidney, liver damage and cardiovascular disease. This study was performed to survey the analysis of anabolic steroids consumption among male and female ...
متن کاملAdolescent anabolic/androgenic steroids: Aggression and anxiety during exposure predict behavioral responding during withdrawal in Syrian hamsters (Mesocricetus auratus).
In the U.S. and worldwide anabolic/androgenic steroid use remains high in the adolescent population. This is concerning given that anabolic/androgenic steroid use is associated with a higher incidence of aggressive behavior during exposure and anxiety during withdrawal. This study uses pubertal Syrian hamsters (Mesocricetus auratus) to investigate the hypothesis that an inverse behavioral relat...
متن کامل